期刊
CLINICAL NUTRITION
卷 33, 期 4, 页码 596-602出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2013.10.003
关键词
Metabolic syndrome; Alcohol; Cohort study; Meta-analysis
资金
- National Natural Science Foundation of China [81270916, 81000317, 81170766]
- Research Fund for the Doctoral Program
- New Teacher Program of the Higher Education of China [20100171110069, 20100171120080]
Background & aims: Epidemiological evidence suggests that alcohol consumption is related to the incidence and development of metabolic syndrome. However, data on this issue are unstable and controversial. We conducted a meta-analysis to provide a quantitative assessment of the association between alcohol intake and risk of metabolic syndrome. Methods: We searched the Pubmed and Embase databases up to May 2013 to identify prospective cohort studies related to alcohol consumption and metabolic syndrome. Summary effect estimates with 95% confidence intervals (Cl) were derived using a fixed or random effects model, depending on the heterogeneity of the included studies. Results: Six prospective studies involving 28,862 participants with 3305 cases of metabolic syndrome were included in the meta-analysis. On the basis of the Newcastle Ottawa Scale system, 83.3% of the studies were identified as relatively high-quality. In our primary analysis, compared with nondrinker, very light drinker was associated with decreased risk of metabolic syndrome [pooled relative risk (RR) 0.86, 95% CI: 0.75-0.99, fixed-effect model] while heavy drinker was associated with increased risk of metabolic syndrome (pooled RR 1.84, 95% CI: 1.34-2.52, fixed-effect model). No indications of heterogeneity and publication bias were found in these two groups. Estimates of total effects were generally consistent in the sensitivity and stratification analyses. Conclusion: The present meta-analysis of prospective studies suggested that heavy alcohol consumption might be associated with an increased risk of metabolic syndrome while very light alcohol consumption seemed to be associated with a reduced risk of metabolic syndrome. (C) 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.
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