期刊
CLINICAL NUTRITION
卷 30, 期 6, 页码 852-857出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2011.05.003
关键词
Triglyceride; Lipid metabolism; Clinical testing
资金
- Greek Governmental Institute
- Department of Internal Medicine
- Sealy Center on Aging, University of Texas Medical Branch at Galveston
- Hellenic Heart Foundation, Athens Greece
- Department of Nutrition and Dietetics, Harokopio University of Athens
Background & aims: Postprandial lipemia is assessed using the oral fat tolerance test (OFTT), a six-hour procedure requiring hourly blood sampling. In order to simplify the test, we investigated whether a) a single postprandial triacylglycerol concentration, b) an OFTT lasting less than six hours or c) an OFTT requiring fewer blood samples, may accurately assess postprandial lipemia under various conditions. Methods: Seventy-two subjects underwent a conventional OFTT. Predictability of single-point concentrations and time-shortened tests was assessed using linear regression and re-sampling analysis. Validity of reduced-sampling tests was assessed using Pearson's correlation coefficients and Bland-Altman analysis. Results: a) A single-point triacylglycerol concentration (3 or 4 h postprandially) did not present significant correlation with postprandial lipemia in the hypetriacylglycerolemic, exercise and energy restriction groups (P>0.05), b) Time-shortened OFTT (4 h) was able to predict postprandial lipemia in every group studied (R(2) = 0.707-0.970, P<0.01), except the hypertriacylglycerolemics (P=0.338), c) Reduced-sampling OFTT (3 or 4 samples) was able to assess postprandial lipemia in every group as well as in the overall sample (r=0.874-0.997, P<0.05). Conclusions: A more convenient, reduced-sampling OFTT may be used alternatively to the conventional OFT, whereas a time-shortened OFTT may be appropriate only for healthy people. (C) 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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