期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 17, 页码 5049-5053出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201411726
关键词
C-H functionalization; copper; heterocycles; ring expansion; TMSCHN2
资金
- Deutscher Akademischer Austauschdienst (DAAD) within the DAAD-PPP Spanien exchange programme [710838]
- Deutsche Forschungsgemeinschaft (DFG)
- Fonds der Chemischen Industrie (FCI)
- DFG [SFB 858]
- Spanish Government [CTQ-2012-12168]
- MICINN
Tricyclic dibenzoxepines and dibenzazepines are important therapeutic agents for the pharmaceutical industry and academic research. However, their syntheses are generally rather tedious, requiring several steps that involve a Wagner-Meerwein-type rearrangement under harsh conditions. Herein, we present the first copper(I)-catalyzed oxidative C-H bond functionalization and ring expansion with TMSCHN2 to yield these important derivatives in a facile and straightforward way.
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