期刊
CLINICAL NUCLEAR MEDICINE
卷 43, 期 9, 页码 648-654出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RLU.0000000000002233
关键词
edema; integrin; intraparenchymal chordoid meningioma; meningioma; PET; CT; PRGD(2)
资金
- National Natural Science Foundation of China [81741142, 81701742, 81601551, 81502156, 81371596]
- National Key Technology Research and Development Program of the Ministry of Science and Technology of China [2014BAI04B01]
- Key Project on Inter-Governmental International Scientific and Technological Innovation Cooperation in National Key Projects of Research and Development Plan [2016YFE0115400]
- Chinese Academy of Medical Science Major Collaborative Innovation Project [2016-I2M-1-011]
- Beijing Municipal Natural Science Foundation [7161012]
- Peking Union Medical College Youth Fund
- Fundamental Research Funds for the Central Universities [2017320003]
- Beijing Key Laboratory of Brain Tumor Project
- National Institute of Biomedical Imaging and Bioengineering
- National Institutes of Health
Objectives Uncommon pathological subtypes of meningioma may present with severe peritumoral brain edema and mimic high-grade glioma (HGG). In a prospective cohort study of Ga-68-NOTA-PRGD2 PET/CT to evaluate glioma, we occasionally observed that a combination of Ga-68-NOTA-PRGD2 and F-18-FDG was able to differentiate these 2 lesion types. Methods From 2013 to 2016, 21 patients suspected of HGG by MRI were recruited for evaluation using Ga-68-NOTA-PRGD2 PET/CT. Brain F-18-FDG PET/CT was performed within 3 days for comparison, and the tumor was surgically removed. The PET results were compared with integrin v3 expression and microvascular density quantification of tumor samples. Results Of the 21 recruited patients, 5 patients were finally pathologically diagnosed as uncommon meningioma with severe peritumoral brain edema, including chordoid meningioma (n = 1), angiomatous meningioma (n = 1), and mixed angiomatous and microcystic meningioma (n = 3). Sixteen were diagnosed as HGG. All the meningioma lesions (n = 5) exhibited intense and homogeneous Ga-68-NOTA-PRGD2 uptake with higher SUVmax on Ga-68-NOTA-PRGD2 PET (1.64-7.86; mean SD, 4.23 +/- 2.48) than the HGG lesions (0.81-2.99; mean +/- SD, 1.57 +/- 0.33; P = 0.0047). Moreover, the uptake ratios of Ga-68-NOTA-PRGD2 over F-18-FDG, normalized as lg100 * SUVmax (RGD / FDG), in the uncommon meningiomas were significantly higher than those in HGG (1.87 +/- 1.36 vs 1.04 +/- 0.87, P = 0.0001). A cutoff value of 1.58 was able to discriminate between these lesion types. There were positive correlations among the expression level of integrin v3, microvascular density, and the tumor-to-background ratio derived from Ga-68-NOTA-PRGD2 PET (P < 0.05). Conclusions This study reveals a specific imaging pattern of uncommon meningioma mimicking HGG, in which Ga-68-NOTA-PRGD2 PET provided added value to F-18-FDG PET.
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