期刊
CLINICAL NUCLEAR MEDICINE
卷 38, 期 3, 页码 E132-E136出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RLU.0b013e31827a278d
关键词
portable imaging gamma- camera; intraoperative imaging; sentinel node biopsy; breast cancer
Purpose: This study aimed to assess the feasibility and potential usefulness of a new intraoperative portable high-resolution imaging gamma-camera for the localization of sentinel lymph node in patients with breast cancer. Methods: Sixteen T1 to T2 breast cancer female patients were evaluated (mean age, 62 years) with preoperative lymphoscintigraphy, acquired 30 minutes after intradermal injection of 60 to 70 MBq (1.6-1.9 mCi) of Tc-99m-nanocolloids in saline volumes of 0.1 to 0.2 mL. Surgery took place the day after (18-20 hours after tracer injection). For intraoperative sentinel lymph node localization, a traditional gamma-probe was used by the surgeon. Moreover, a portable imaging gamma-camera was used by the nuclear physician who was present in the operating room. Results: The portable imaging gamma-camera showed very high spatial resolution (2.4 mm) in the 4.4 x 4.4 cm(2) FOV, with a good sensitivity of 180 cps/MBq at a Plexiglas depth of 1 cm. In 11 patients, lymphoscintigraphy, gamma-probe, and imaging gamma-camera depicted the same number of radioactive lymph nodes (17 nodes; 5 of which were metastatic and detected in 6 different patients). In 6 patients, the portable imaging gamma-camera detected 1 node more than lymphoscintigraphy (in total, 5 nodes more), one of which was metastatic (the only one metastatic in that patient). Conclusions: Our preliminary results showed that a portable high-resolution hand-held imaging gamma-camera is a feasible, not time-consuming, noninvasive procedure in intraoperative sentinel node localization, offering extra confidence to the surgeon. In our hands, it was a very useful auxiliary imaging tool especially in the identification of nodes located deep in the axilla, which are difficult to detect at the preoperative lymphoscintigraphy. Additional multicenter studies involving a greater number of patients are necessary to confirm these promising data.
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