期刊
CLINICAL NUCLEAR MEDICINE
卷 36, 期 8, 页码 669-671出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RLU.0b013e3182175497
关键词
Creutzfeldt-Jakob disease; regional cerebral blood flow; single photon emission tomography; Tc-99m ECD; positron emission tomography
Background: Creutzfeldt-Jakob disease (CJD) is a subacute spongiform encephalopathy characterized by rapidly progressive dementia, hard to diagnose during life. Materials and Methods: We present a case of a patient with pathologically confirmed sporadic form of CJD in whom initial diagnostic tests were negative. Two sequential brain single-photon emission computed tomography with Tc-99m ethyl-cysteinate dimer were performed, the first one was performed few days after the admission into hospital and the second, 1 month later. Results: Both studies revealed a decrease in regional cerebral blood flow indicative of neuronal dysfunction, more pronounced in the second study. Conclusion: Current radionuclide scintigraphy can be an useful tool for the investigation of CJD.
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