期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 17, 页码 5152-5156出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201412129
关键词
cell microcarriers; chitin nanofibers; microspheres; nanofibrous architecture; self-assembly
资金
- National Basic Research Program of China (973 Program) [2010CB732203]
- Major Program of National Natural Science Foundation of China [21334005]
- National Natural Science Foundation of China [20874079]
In this work, chitin microspheres (NCM) having a nanofibrous architecture were constructed using a bottom-up fabrication pathway. The chitin chains rapidly self-assembled into nanofibers in NaOH/urea aqueous solution by a thermally induced method and subsequently formed weaved microspheres. The diameter of the chitin nanofibers and the size of the NCM were tunable by controlling the temperature and the processing parameters to be in the range from 26 to 55 nm and 3 to 130 mu m, respectively. As a result of the nanofibrous surface and the inherent biocompatibility of chitin, cells could adhere to the chitin microspheres and showed a high attachment efficiency, indicating the great potential of the NCM for 3D cell microcarriers.
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