期刊
CLINICAL NEUROPSYCHOLOGIST
卷 23, 期 3, 页码 446-461出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/13854040802360558
关键词
Memory; Executive functioning; Everyday function; Dementia; Alzheimer's disease
资金
- National Institute on Aging [AG10129, AG021511, AG12435, P50AG16570]
- California Department of Health Services Alzheimer's Disease Program
- Veterans Affairs Northern California Health Care System
- NATIONAL INSTITUTE ON AGING [R01AG021028, K23AG021511, P30AG010129, R01AG031252, P50AG016570, P01AG012435] Funding Source: NIH RePORTER
Impaired everyday function is a diagnostic criterion for dementia, and a determinant of healthcare utilization and caregiver burden. Although many previous studies have demonstrated a cross-sectional relationship between cognition (particularly executive functions and memory) and everyday function in older adults, very little is known about longitudinal relationships between these domains. This study examined the association between longitudinal change in episodic memory (MEM) and executive functioning (EXEC) and change in everyday function. Participants were a cognitively heterogeneous group of 100 elderly persons including those with normal cognition, as well as those with mild cognitive impairment and dementia. They were followed for an average of 5 years. Random effects modeling showed that change in both MEM and EXEC were independently associated with rate of change in informant-rated instrumental activities of daily living (IADLs), even after controlling for age, education, and gender. Findings indicate that declines in MEM and EXEC over time make unique and independent contributions to declines in older adults' ability to function in daily life.
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