期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 34, 页码 9871-9875出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201503792
关键词
chemical evolution; day-night cycle; depsipeptides; origins-of-life; proto-peptides
资金
- NSF
- NASA Astrobiology Program under the NSF Center for Chemical Evolution [CHE-1004570]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1004570] Funding Source: National Science Foundation
Although it is generally accepted that amino acids were present on the prebiotic Earth, the mechanism by which alpha-amino acids were condensed into polypeptides before the emergence of enzymes remains unsolved. Here, we demonstrate a prebiotically plausible mechanism for peptide (amide) bond formation that is enabled by alpha-hydroxy acids, which were likely present along with amino acids on the early Earth. Together, alpha-hydroxy acids and alpha-amino acids form depsipeptides-oligomers with a combination of ester and amide linkages-in model prebiotic reactions that are driven by wet-cool/dry-hot cycles. Through a combination of ester-amide bond exchange and ester bond hydrolysis, depsipeptides are enriched with amino acids over time. These results support a long-standing hypothesis that peptides might have arisen from ester-based precursors.
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