期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 2, 页码 794-797出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201508309
关键词
alkynes; C-H functionalization; gold carbenoids; gold catalysis; indoles
资金
- CSC (China Scholarship Council)
- Athenaeum Foundation
The gold-catalyzed C-H annulation of anthranil derivatives with alkynes offers a facile, flexible, and atom-economical one-step route to unprotected 7-acylindoles. An intermediate a-imino gold carbene, generated by an intermolecular reaction, promotes ortho-aryl C-H functionalization to afford the target products. The transformation proceeds with a broad range of substrates under mild conditions. Moreover, the obtained functionalized indole products represent a versatile platform for the construction of diverse indolyl frameworks.
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