期刊
CLINICAL NEUROPHYSIOLOGY
卷 122, 期 11, 页码 2227-2235出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2011.04.011
关键词
Schizophrenia; Lempel-Ziv complexity; Magnetoencephalography; Neurodevelopmental; Neurodegenerative
资金
- FUNDACION MUTUA MADRI-LENA
- Lilly S.A. Spain
- Serono
- Organon
- Pfizer
- Eli Lilly
- Bristol-Myers Squibb
- Lundbeck
- Servier
- Janssen-Cilagg Lundbeck
- Boehringer-Ingelheim
- Jansen-Organon
- Wyeth
Objective: The neurodevelopmental-neurodegenerative debate is a basic issue in the field of the neuropathological basis of schizophrenia (SCH). Neurophysiological techniques have been scarcely involved in such debate, but nonlinear analysis methods may contribute to it. Methods: Fifteen patients (age range 23-42 years) matching DSM IV-TR criteria for SCH, and 15 sex-and age-matched control subjects (age range 23-42 years) underwent a resting-state magnetoencephalographic evaluation and Lempel-Ziv complexity (LZC) scores were calculated. Results: Regression analyses indicated that LZC values were strongly dependent on age. Complexity scores increased as a function of age in controls, while SCH patients exhibited a progressive reduction of LZC values. A logistic model including LZC scores, age and the interaction of both variables allowed the classification of patients and controls with high sensitivity and specificity. Conclusions: Results demonstrated that SCH patients failed to follow the normal'' process of complexity increase as a function of age. In addition, SCH patients exhibited a significant reduction of complexity scores as a function of age, thus paralleling the pattern observed in neurodegenerative diseases. Significance: Our results support the notion of a progressive defect in SCH, which does not contradict the existence of a basic neurodevelopmental alteration. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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