期刊
CLINICAL NEUROPHYSIOLOGY
卷 122, 期 12, 页码 2452-2461出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2011.04.022
关键词
Spinal cord injury; Repetitive transcranial magnetic stimulation; ASIA impairment scale; Motor evoked potentials; Electrical perceptual threshold; Sympathetic skin response
资金
- International Spinal Research Trust (ISRT) [CLI007]
Objective: To assess the effectiveness of physiological outcome measures in detecting functional change in the degree of impairment of spinal cord injury (SCI) following repetitive transcranial magnetic stimulation (rTMS) of the sensorimotor cortex. Methods: Subjects with complete or incomplete cervical (or T1) SCI received real and sham rTMS in a randomised placebo-controlled single-blinded cross-over trial. rTMS at sub-threshold intensity for upper-limb muscles was applied (5 Hz, 900 stimuli) on 5 consecutive days. Assessments made before and for 2 weeks after treatment comprised the ASIA (American Spinal Injuries Association) impairment scale (AIS), the Action Research Arm Test (ARAT), a peg-board test, electrical perceptual test (EPT), motor evoked potentials, cortical silent period, cardiovascular and sympathetic skin responses. Results: There were no significant differences in AIS outcomes between real and sham rTMS. The ARAT was increased at 1 h after real rTMS compared to baseline. Active motor threshold for the most caudally innervated hand muscle was increased at 72 and 120 h compared to baseline. Persistent reductions in EPT to rTMS occurred in two individuals. Conclusions: Changes in cortical motor threshold measures may accompany functional gains to rTMS in SCI subjects. Significance: Electrophysiological measures may provide a useful adjunct to ASIA impairment scales. (C) 2011 Published by Elsevier Ireland Ltd. on behalf of International Federation of Clinical Neurophysiology.
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