期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 13, 页码 3967-3972出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201411408
关键词
blood-brain barrier; enantioselectivity; membranes; peptides; receptors
资金
- ARAID
- MINECO-FEDER [BIO2013-40716, BFU-2009-0786, BFU-2012-33932]
- Generalitat de Catalunya [XRB, 2014-SGR-521]
- La Caixa/IRB Barcelona fellowship
- FARA
- FEDAES/GENEFA
- BABEL FAMILY
The blood-brain barrier (BBB) is a formidable physical and enzymatic barrier that tightly controls the passage of molecules from the blood to the brain. In fact, less than 2% of all potential neurotherapeutics are able to cross it. Here, by applying the retro-enantio approach to a peptide that targets the transferrin receptor, a full protease-resistant peptide with the capacity to act as a BBB shuttle was obtained and thus enabled the transport of a variety of cargos into the central nervous system.
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