期刊
CLINICAL NEUROPHYSIOLOGY
卷 121, 期 1, 页码 90-93出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2009.07.048
关键词
Plasticity; Aging; Dopamine; Transcranial magnetic stimulation
资金
- MEXT of Japan [20019023]
- Japan Society for the Promotion of Science [21613003]
- Grants-in-Aid for Scientific Research [22790824] Funding Source: KAKEN
Objective: To test whether the normal aging itself may change the cortical plasticity in human. Methods: Motor-evoked potentials (MEPs) were measured from 48 right-handed healthy volunteers (age 21-79) before and after the paired associative stimulation (PAS), comprising a single electric stimulus to the right median nerve at wrist and subsequent transcranial magnetic stimulation (TMS) of the left primary motor cortex. Results: The magnitude of MEP increased by PAS in the young and middle but not in the elderly and its change was negatively correlated with the age. Conclusions: These results suggest that the human M1 shows age-dependent reduction of cortical plasticity. Significance: The reduction of the M1 plasticity maybe caused by the attenuated responsiveness of intracortical circuits in the M1 and/or disrupted sensorimotor integration within basal ganglia-thalamocortical loop. (C) 2009 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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