期刊
CLINICAL NEUROPHYSIOLOGY
卷 121, 期 10, 页码 1669-1679出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2009.12.041
关键词
Motor neuron; Motoneuron; Persistent inward current; Amyotrophic lateral sclerosis; Spinal cord injury
资金
- National Institutes of Health [F31 NS060532, R01 NS051462]
- Canadian Institutes of Health Research
- ALS Society of Canada
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS034382, F31NS060532, R01NS051462] Funding Source: NIH RePORTER
Meaningful body movements depend on the interplay between synaptic inputs to motoneurons and their intrinsic properties. Injury and disease often alter either or both of these factors and cause motoneuron and movement dysfunction. The ability of the motoneuronal membrane to generate persistent inward currents (PICs) is especially potent in setting the intrinsic excitability of motoneurons and can drastically change the motoneuron output to a given input. In this article, we review the role of PICs in modulating the excitability of spinal motoneurons during health, and their contribution to motoneuron excitability after spinal cord injury (SCI) and in amyotrophic lateral sclerosis (ALS) leading to exaggerated long-lasting reflexes and muscle spasms, and contributing to neuronal degeneration, respectively. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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