期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 49, 页码 14768-14771出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201507530
关键词
electron transfer; imaging agents; luminescence; membrane permeability; reactive oxygen species
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [20117003, 23249004, 26111012, 25113707, 15H05951]
- Daiichi-Sankyo Foundation of Life Science
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- JSPS Core-to-Core Program, A. Advanced Research Networks
- Berthold Japan K.K.
- Grants-in-Aid for Scientific Research [26104509, 23249004, 25113707, 15H05951, 20117003] Funding Source: KAKEN
A sensitive bioluminogenic probe for highly reactive oxygen species (hROS), SO3H-APL, was developed based on the concept of dual control of bioluminescence emission by means of bioluminescent enzyme-induced electron transfer (BioLeT) and modulation of cell-membrane permeability. This probe enables non-invasive visualization of physiologically relevant amounts of hROS generated deep inside the body of living rats for the first time. It is expected to serve as a practical analytical tool for investigating a wide range of biological functions of hROS in vivo. The design concept should be applicable to other in vivo bioluminogenic probes.
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