期刊
CLINICAL NEUROPHYSIOLOGY
卷 119, 期 5, 页码 1201-1212出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2008.01.019
关键词
EEG; pain; primary somatosensory cortex; second somatosensory cortex; insula
资金
- NINDS NIH HHS [N43 NS000001-2337] Funding Source: Medline
Objective: To identify EEG features that index pain-related cortical activity, and to identify factors that can mask the pain-related EEG features and/or produce features that can be misinterpreted as pain-specific. Methods: The EEG was recorded during three conditions presented in counterbalanced order: a tonic cold pain condition, and pain anticipation and arithmetic control conditions. The EEG was also recorded while the subjects made a wincing facial expression to estimate the contribution of scalp EMG artifacts to the pain-related EEG features. Results: Alpha amplitudes decreased over the contralateral temporal scalp and increased over the posterior scalp during the cold pain condition. There was an increase in gamma band activity during the cold pain condition at most electrode locations that was due to EMG artifacts. Conclusions: The decrease in alpha over the contralateral temporal scalp during cold pain is consistent with pain-related activity in the primary somatosensory cortex and/or the somatosensory association areas located in the parietal operculum and/or insula. This study also identified factors that might mask the pain-related EEG features and/or generate EEG features that could be misinterpreted as being pain-specific. These include (but are not limited to) an increase in alpha generated in the visual cortex that results from attention being drawn towards the pain; the widespread increase in gamma band activity that results from scalp EMG generated by the facial expressions that often accompany pain; and the possibility that non-specific changes in the EEG over time mask the pain-related EEG features when the pain and control conditions are given in the same order across subjects. Significance: This study identified several factors that need to be controlled and/or isolated in order to successfully record EEG features that index pain-related activity in the somatosensory cortices. (c) 2008 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据