期刊
CLINICAL NEUROPHYSIOLOGY
卷 119, 期 4, 页码 805-811出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2007.12.001
关键词
transcranial direct current stimulation (tDCS); tactile acuity; somatosensory cortex; grating orientation task (GOT); perceptual; cortical plasticity
资金
- Intramural NIH HHS [Z01 NS002978-09] Funding Source: Medline
Objective: Non-invasive brain stimulation such as transcranial direct current stimulation (tDCS) has been successfully used to induce polarity-specific excitability changes in the brain. However, it is still unknown if anodal tDCS (tDCS nodal) applied to the primary somatosensory cortex (S1) can lead to behavioral changes in performance of tactile discriminative tasks. Methods: Using an accurate tactile discrimination task (grating orientation task: GOT) we tested the hypothesis that application of 1 mA of tDCS(anodal) (current density at the electrodes of 0.04 mA/cm(2)) over the left S1 can lead to an improved tactile spatial acuity in the contralateral index-finger (IF). Results: Performance in the GOT task with the contralateral IF but not with the ipsilateral IF was enhanced for about 40 min after a 20 min application of tDCS(anodal) in the absence of changes with sham stimulation. Conclusions: These results provide the first evidence that tDCS(anodal) over S1 improves performance in a complex somatosensory task beyond the period of stimulation. Significance: The ability to induce performance improvement in the somatosensory domain with tDCS applied over SI could be used to promote functional recovery in patients with diminished tactile perception. (c) Published by Elsevier Ireland Ltd on behalf of International Federation of Clinical Neurophysiology.
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