期刊
CLINICAL NEUROPHYSIOLOGY
卷 119, 期 10, 页码 2274-2281出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2008.06.011
关键词
Grip; Load; Coordination; Performance; Impairment
资金
- National Multiple Sclerosis Society
- Serbian Research Council
Objective: To evaluate the methodology for exploring the specific aspects of functional impairment in multiple sclerosis (MS) through the pattern of forces exerted in various manipulation tasks. Methods: Twelve mildly involved MS patients (EDSS 2.5-5.5) and 12 healthy controls performed various static and dynamic manipulation tasks with an instrumented device that recorded the grip (G: normal to the digit device contact area) and load force (L; tangential force that causes lifting). Results: MS patients consistently displayed lower indices of task performance (as assessed by the ability to produce the required L Profiles) and force coordination (as assessed by G/L ratio, coupling of G and L, and G modulation) than the healthy controls across all tested tasks. Conclusions: The applied methodology could be sensitive enough to detect the hand dysfunction in mildly involved individuals with MS. Particularly recommended for future evaluations of the impairment of hand function could be a simple lifting task and the static task of tracing a gradually changing L, as well as the variables depicting both the task performance and G/L ratio. Significance: The applied methodology could be developed into a standard clinical test for the assessment of hand function in MS and, possibly, in other neurological diseases. (c) 2008 International Federation of clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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