期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 12, 页码 3639-3642出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201409952
关键词
hydrogel; nanostructures; oligomerization; self-assembly
资金
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- National Natural Science Foundation of China [21175122, 91127036, 21375121]
- Fundamental Research Funds for Central Universities [WK2060190018]
Polymer hydrogels and small-molecule-based (SMB) supramolecular hydrogels have been widely explored. But oligomeric hydrogels have remained a challenge because synthetic difficulties of the oligomers and control of their amphiphilicities. Reported herein is the rational design of two precursors Cys(SEt)-Lys-CBT (1) and (Cys-Lys-CBT) 2 (2) (CBT-2-cyano-6-aminobenzothiazole) and the use of a biocompatible condensation to prepare oligomeric hydrogels. Glutathione reduction of 1 or 2 yields the same gelator CysLys-CBT (3) which condenses with each other to yield amphiphilic cyclic oligomers. The oligomers instantly self-assemble into nanofibers and form oligomeric hydrogels with similar mechanic properties. Chemical analyses indicated that the major condensation product in both two hydrogels is a cyclic dimer. Considering its biocompatibility, optimal mechanical strength, and biodegradability, we believe that our oligomeric hydrogel might be useful for long-term drug delivery in the future.
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