期刊
CLINICAL NEUROPHARMACOLOGY
卷 35, 期 3, 页码 118-120出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNF.0b013e31824d529b
关键词
Parkinson disease; pathological gambling; dopamine replacement therapy; opioid antagonist; naltrexone
Pathological gambling (PG) is a potential complication related to the treatment of Parkinson disease (PD) with dopamine agonists (DA). The cause of this disorder is unknown, but altered dopamine neurotransmission may be involved. Objective: We evaluated the efficacy and tolerability of the opioid antagonist naltrexone in the treatment of PG in PD. Methods: Our cases included 3 patients with PD who developed PG after DA treatment. Results: Pathological gambling did not improve after reduction or discontinuation of DA. These patients responded poorly to serotonin reuptake inhibitors, whereas treatment with opioid antagonist naltrexone resulted in the remission of PG. Naltrexone treatment was well tolerated. In one patient, higher dose of naltrexone resulted in hepatic abnormalities, which resolved after dosage reduction. Conclusions: The opioid antagonist naltrexone could be an effective option for the treatment of PG in PD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据