期刊
CLINICAL NEPHROLOGY
卷 77, 期 6, 页码 438-444出版社
DUSTRI-VERLAG DR KARL FEISTLE
DOI: 10.5414/CN107278
关键词
fluid balance; acute kidney injury
Background: We hypothesized that positive fluid balance (FB) is the result of intraoperative kidney injury and associated renal vasoconstriction, and therefore may be an early clinical indicator of acute kidney injury (AKI). Since rapid changes in fluid volume occur during cardiovascular (CV) surgery, we investigated the influence of immediate postoperative FB on AKI. Materials and methods: Data from the Nesiritide Study were retrospectively analyzed to investigate the association between FB and AKI. Results: Patients were classified into a negative FB (NegFB, median -1,221 ml, IQR -1,974 to -653 ml, n = 71) and a PosFB (median 849 ml, IQR 328 -1,552 ml, n = 19) group based on FB status in the first 24 h postoperatively. The PosFB group had a higher incidence of AKI (NegFB 25.3% vs. PosFB 47.3%, p = 0.090) compared to the NegFB group. The difference in the incidence of AKI was significantly higher (NegFB 25.3% vs. highPosFB 80%, p = 0.001) in the subset of patients who had FB >= 849 ml (highPosFB, n = 10). The highPosFB group demonstrated a significantly elevated risk for AKI in both unadjusted (OR = 9.8, 95% CI 1.9 - 51.2, p = 0.007) and multivariate models (OR = 8.1, 95% CI 1.5 - 45.1, p = 0.03). Conclusions: PosFB in the immediate postoperative period may be an independent early indicator of AKI in patients undergoing CV surgery.
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