期刊
CLINICAL NEPHROLOGY
卷 77, 期 3, 页码 188-195出版社
DUSTRI-VERLAG DR KARL FEISTLE
DOI: 10.5414/CN107266
关键词
iron deficiency; anemia of CKD; end stage renal disease; intravenous iron
Iron deficiency is a common cause of anemia in patients with end stage renal disease (ESRD). Intravenous iron administration, especially in those requiring treatment with erythropoiesis stimulating agents (ESA) is an essential component of the management of anemia in ESRD patients. Iron improves hemoglobin, reduces ESA dose requirement and also has non-erythropoietic effects including improvement in physical performance, cognition and amelioration of restless leg syndrome. However, iron can promote oxidative stress, cause endothelial dysfunction, inflammation and tissue injury, and has a potential to cause progression of both CKD and cardiovascular disease. In this review, we discuss the benefits and risks associated with i.v. iron and the practical aspects of iron administration that can minimize the complications related to iron therapy in ESRD.
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