期刊
CLINICAL MICROBIOLOGY REVIEWS
卷 25, 期 4, 页码 708-+出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CMR.00021-12
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资金
- Office of the Director, U.S. National Institutes of Health [DP2OD006663]
- United Kingdom National Institute for Health Research [SR-2011-04-001]
- EPSRC [EP/I031626/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I031626/1] Funding Source: researchfish
Numerous studies have reported that individuals can simultaneously harbor multiple distinct strains of Mycobacterium tuberculosis. To date, there has been limited discussion of the consequences for the individual or the epidemiological importance of mixed infections. Here, we review studies that documented mixed infections, highlight challenges associated with the detection of mixed infections, and discuss possible implications of mixed infections for the diagnosis and treatment of patients and for the community impact of tuberculosis control strategies. We conclude by highlighting questions that should be resolved in order to improve our understanding of the importance of mixed-strain M. tuberculosis infections.
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