期刊
CLINICAL MICROBIOLOGY REVIEWS
卷 24, 期 1, 页码 193-+出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CMR.00044-10
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资金
- University of Minnesota International Center for Antiviral Research and Epidemiology
- Minnesota Medical Foundation
- National Institutes of Health [DK 13083, T32-CA009138, F31AI084524]
- NATIONAL CANCER INSTITUTE [T32CA009138] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [F31AI084524] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P01DK013083] Funding Source: NIH RePORTER
Epstein-Barr virus (EBV) is a gammaherpesvirus that infects a large fraction of the human population. Primary infection is often asymptomatic but results in lifelong infection, which is kept in check by the host immune system. In some cases, primary infection can result in infectious mononucleosis. Furthermore, when host-virus balance is not achieved, the virus can drive potentially lethal lymphoproliferation and lymphomagenesis. In this review, we describe the biology of EBV and the host immune response. We review the diagnosis of EBV infection and discuss the characteristics and pathogenesis of infectious mononucleosis. These topics are approached in the context of developing therapeutic and preventative strategies.
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