期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 20, 期 -, 页码 54-59出版社
WILEY-BLACKWELL
DOI: 10.1111/1469-0691.12495
关键词
Aspergillus; Candida; mutations; mycosis; tandem repeat
资金
- Astellas Pharma
- bioMerieux
- Gilead Sciences
- Merck Sharp and Dohme
- Pfizer
- Schering Plough
- Soria Melguizo SA
- Ferrer International
- European Union
- ALBAN programme
- Spanish Agency for International Cooperation
- Spanish Ministry of Culture and Education
- Spanish Health Research Fund
- Instituto de Salud Carlos III
- Ramon Areces Foundation
- Mutua Madrilena Foundation
The phenotypic methods for identification of antifungal resistance are reliable procedures, and MIC determination by reference techniques is the gold standard to detect resistant clinical isolates. In recent years, progress has been made towards the description of resistance mechanisms at molecular level. There are methods of detection that can be useful for clinical laboratories, but lack of standardization precludes their full and effective integration in the routine daily practice. The molecular detection of Candida resistance to azoles and to echinocandins and of Aspergillus resistance to triazoles can be clinically relevant and could help to design more efficient prevention and control strategies. This text reviews the present state of the detection of mechanisms of resistance at the molecular level in Candida spp. and Aspergillus spp. and its relevance to clinical practice.
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