期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 20, 期 11, 页码 O854-O856出版社
WILEY-BLACKWELL
DOI: 10.1111/1469-0691.12614
关键词
Biofilm; lipopolysaccharide; melioidosis; pseudomallei; relapse
资金
- Thailand Research Fund [MRG5480172]
- Melioidosis Research Centre, Khon Kaen University, Thailand
- Wellcome Trust [090219/Z/09/Z]
- National Institute for Health Research Cambridge Biomedical Research Centre
- Wellcome Trust [090219/Z/09/Z] Funding Source: Wellcome Trust
We examined whether quantitative biofilm formation and/or lipopolysaccharide type of Burkholderia pseudomallei was associated with relapsing melioidosis. We devised a 1:4 nested case-control study in which both cases and controls were drawn from a cohort of patients with primary melioidosis. Paired isolates from 80 patients with relapse and single isolates from 184 patients without relapse were tested. Relapse was associated with biofilm formation of the primary infecting isolate (conditional OR2.03; 95%CI1.27-3.25; p0.003), but not with lipopolysaccharide type (p0.74). This finding highlights the importance of biofilm formation in relapsing melioidosis.
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