期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 19, 期 10, 页码 E447-E450出版社
ELSEVIER SCI LTD
DOI: 10.1111/1469-0691.12233
关键词
Cervical cancer; human papillomavirus 18; molecular marker; physical status; risk assessment
资金
- Fundacao para a Ciencia e Tecnologia
The aim of this work was to assess the value of the physical status of human papillomavirus (HPV) DNA as a disease marker for cervical cancer development in a set of 248 DNA samples previously genotyped as HPV 16 or 18, by calculating the E2/E6 ratio through real-time PCR. There was a significant difference in integration status according to disease grade for both genotypes (p<0.001). Furthermore, especially for HPV 18, determining the DNA physical status could be a useful biomarker in predicting cervical cancer risk development, with a lower E2/E6 ratio clinically associated with the development of a precancerous lesion.
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