期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 17, 期 3, 页码 382-385出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1469-0691.2010.03295.x
关键词
Clone; cross-infection; cystic fibrosis; MLST; Pseudomonas aeruginosa
资金
- Ipsat therapies
- 3M
- Cepheid
- Novartis
- Bayer
- Pfizer
- Netherlands Organization for Scientific Research (VICI NWO) [918.76.611]
Studies suggest that infection with highly prevalent Pseudomonas aeruginosa clones in cystic fibrosis (CF) is associated with an unfavourable clinical outcome. We studied the clinical characteristics of patients infected with a recently described, highly prevalent P. aeruginosa clone (ST406) in two CF centres in The Netherlands. Multilocus sequence typing data were available for 219 patients, of whom 40 (18.3%) were infected with ST406 and 179 with other sequence types. ST406 infection was independently associated with age, having a sibling with ST406 infection and use of inhaled antibiotics, but not with unfavourable clinical outcome, suggesting that high transmissibility is not necessarily associated with high virulence.
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