期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 17, 期 9, 页码 1332-1335出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1469-0691.2010.03313.x
关键词
Drug-resistant mutation; in vitro selection; influenza B virus; NA inhibitor; neuraminidase
资金
- Founding Research Centers for Emerging and Reemerging Infectious Diseases
- ERATO (Japan Science and Technology Agency)
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- National Institute of Allergy and Infectious Diseases Public Health Service (USA)
We and others have previously isolated influenza B viruses with reduced sensitivity to neuraminidase (NA) inhibitors (oseltamivir and zanamivir) from patients who were never exposed to these drugs. It was unclear whether the NA substitutions found in these influenza B isolates arose spontaneously or were caused by selective pressure. Here, we obtained influenza B viruses with reduced NA inhibitor sensitivity by in vitro selection with NA inhibitors. We found that these viruses possessed the same NA substitutions as those previously found in viruses isolated from untreated patients. These results suggest that these NA substitutions were selected in patients who were treated with an NA inhibitor and that the resistant variants were then transmitted to others.
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