期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 16, 期 8, 页码 1282-1284出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1469-0691.2009.03104.x
关键词
Diagnosis; IFN-gamma; IL-2; latent infection; tuberculosis
资金
- EC [LSHP-CT-2006-037326]
- Ricerca Finalizzata [06.76.1]
P>Effective control of tuberculosis (TB) includes discrimination of subjects with active TB from individuals with latent TB infection (LTBI). As distinct interferon (IFN)-gamma and interleukin (IL)-2 profiles of antigen-specific T-cells have been associated with different clinical stages and antigen loads in several viral and bacterial diseases, we analysed these cytokines in TB using a modified QuantiFERON-TB Gold In Tube test. Detection of IL-2 in addition to IFN-gamma distinguishes not only Mycobacterium tuberculosis-infected subjects from healthy controls, but also individuals with LTBI from active TB patients. This may help to improve diagnostic tests for TB.
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