期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 15, 期 2, 页码 144-148出版社
ELSEVIER SCI LTD
DOI: 10.1111/j.1469-0691.2008.02650.x
关键词
Antibody; human; infection; Panton-Valentine leukocidin; Staphylococcus aureus
资金
- Ministere de la Recherche et des Nouvelles Technologies
To determine whether Staphylococcus aureus Panton-Valentine leukocidin (PVL) is expressed during human infection, anti-PVL antibody titres were compared in patients with PVL-positive and PVL-negative staphylococcal infections, and in patients with no evidence of S. aureus infection. Patients with PVL-positive strains had higher levels of anti-PVL antibodies than individuals of both control groups. The median anti-PVL titre increased 8.6-fold during the course of PVL-positive infection and 1.4-fold during PVL-negative infection. These results indicate that only PVL-positive S. aureus strains elicit significant anti-PVL antibody production in humans, and demonstrate the production of PVL during PVL-positive S. aureus infection. The protective role of this immune response remains to be established.
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