期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 15, 期 3, 页码 289-292出版社
ELSEVIER SCI LTD
DOI: 10.1111/j.1469-0691.2008.02653.x
关键词
Candidaemia; fluconazole; intensive-care unit; prevention; prophylaxis
A matched case-control study was conducted to determine the risk factors for development of candidaemia in patients requiring intensive-care unit (ICU) treatment for more than 48 h. Patients were matched according to length of ICU stay, age, department of admission, year of admission and sex. Forty-five patients with candidaemia were identified (0.6 cases/1000 patient-days). Candidaemia developed mainly in critically ill patients with multiple organ failure and end-stage disease. Candida colonization and gastrointestinal surgery were independently associated with candidaemia. ICU and total in-hospital mortality were 40% and 66.7%, respectively. Candidaemia-related mortality was 20%. Candidaemia treatment failure was the only variable associated with in-hospital mortality (p 0.008).
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