期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 23, 页码 6887-6892出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201501840
关键词
2-substituent effect; kinetics; mechanistic studies; N-heterocyclic carbenes; organocatalysis
资金
- Royal Society
- EPSRC [EP/G013268/1]
- European Research Council under the European Union's Seventh Framework Programme (FP7) ERC [279850]
- EPSRC [EP/G013268/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/G013268/1] Funding Source: researchfish
Rate and equilibrium constants for the reaction between N-aryl triazolium N-heterocyclic carbene (NHC) precatalysts and substituted benzaldehyde derivatives to form 3-(hydroxybenzyl)azolium adducts under both catalytic and stoichiometric conditions have been measured. Kinetic analysis and reaction profile fitting of both the forward and reverse reactions, plus onwards reaction to the Breslow intermediate, demonstrate the remarkable effect of the benzaldehyde 2-substituent in these reactions and provide insight into the chemoselectivity of cross-benzoin reactions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据