期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 14, 期 4, 页码 295-297出版社
ELSEVIER SCI LTD
DOI: 10.1111/j.1469-0691.2007.01930.x
关键词
AAC(6')-Ib-cr; plasmid-mediated; QepA; QnrA; quinolones; resistance
Although resistance to quinolones is commonly chromosomally-encoded in Enterobacteriaceae, the emergence of plasmid-mediated quinolone resistance (PMQR) has also been reported, with at least three known resistance mechanisms to date, i.e., Qnr, aminoglycoside acetyltransferase AAC(6')-Ib-cr and QepA. Qnr proteins protect target enzymes (DNA gyrase and type IV topoisomerase) from quinolone inhibition, the AAC(6')-Ib-cr enzyme acetylates norfloxacin and ciprofloxacin, and the QepA efflux pump extrudes hydrophilic fluoroquinolones. Although these PMQR determinants confer only low-level resistance to quinolones and/or fluoroquinolones, they may provide a favourable background in which the selection of additional chromosomally-encoded quinolone resistance mechanisms can occur.
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