期刊
CLINICAL LIPIDOLOGY
卷 9, 期 4, 页码 407-415出版社
FUTURE MEDICINE LTD
DOI: 10.2217/CLP.14.22
关键词
carotid intima-media thickness; Chinese; high-density lipoprotein subclasses; lipid; low-density lipoprotein subclasses
资金
- Chinese Medical Association Foundation
- Chinese Diabetes Society [07020470055]
Aims: To determine whether lipoprotein subclasses are associated with the carotid intima-media thickness (IMT) in Chinese population. Patients & methods: Total cholesterol (TC), triglycerides, high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) were measured by standard enzymatic methods. The subclasses of LDL were determined by 1D gradient gel electrophoresis and subclasses of HDL were determined by 2D gradient gel electrophoresis in 342 participants. Carotid IMT was measured by means of high-resolution vascular ultrasound. Results: In multivariate ana-lysis, TC and LDL-C levels were positively correlated with the carotid IMT (p < 0.001). In stepwise multiple regression ana-lysis, small dense LDL was found to be significantly associated with IMT after adjustment for other metabolic risks and traditional lipids such as triglycerides, TC and HDL-C. Additionally, HDL subclasses were not correlated with IMT. Conclusion: Small dense LDL was a stronger predictor for carotid atherosclerosis in the general Chinese population when compared with HDL-C or HDL subclasses, which is independent of lipids and other related metabolic risks.
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