期刊
CLINICAL LIPIDOLOGY
卷 4, 期 2, 页码 245-265出版社
FUTURE MEDICINE LTD
DOI: 10.2217/CLP.09.8
关键词
adipogenesis; adipogenic differentiation; myogenesis; satellite cell; skeletal muscle; stem cell
资金
- Fondazione Citta della Speranza, Onlus
- Ricerca Sanitaria Finalizzata Regione Veneto [2007BRR57M_004]
Satellite cells (SCs) are undifferentiated skeletal muscle cells that allow muscular growth and regeneration. Since their first description, SCs were simply considered myogenic precursors, but now it is widely accepted that SCs are a heterogeneous stem cell population characterized by plasticity and self-renewal. In this report we focus on SCs capacity to undergo adipogenic differentiation both spontaneous and induced by adipogenic factors. Understanding SC behavior is especially important because their adipogenic potential could represent a pathophysiological explanation for the intramuscular fat depots and associated insulin resistance that characterize many metabolic diseases and age-related sarcopenia. Moreover, SC are a therapeutic promise for neuromuscular diseases in the context of tissue engineering, representing an interesting cell source for implantation.
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