期刊
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
卷 10, 期 8, 页码 1459-1469出版社
AMER SOC NEPHROLOGY
DOI: 10.2215/CJN.04680514
关键词
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资金
- National Institutes of Health (NIH) [R01-DK080067]
- O'Brien Center grant [P30-DK079312]
- Dialysis Clinics Inc.
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK107623, P30DK079312, R01DK080067, R01DK099345] Funding Source: NIH RePORTER
The innate immune system is the first line of defense in response to nonself and danger signals from microbial invasion or tissue injury. It is increasingly recognized that each organ uses unique sets of cells and molecules that orchestrate regional innate immunity. The cells that execute the task of innate immunity are many and consist of not only professional immune cells but also nonimmune cells, such as renal epithelial cells. Despite a high level of sophistication, deregulated innate immunity is common and contributes to a wide range of renal diseases, such as sepsis-induced kidney injury, GN, and allograft dysfunction. This review discusses how the innate immune system recognizes and responds to nonself and danger signals. In particular, the roles of renal epithelial cells that make them an integral part of the innate immune apparatus of the kidney are highlighted.
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