期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 13, 页码 4032-4035出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201410814
关键词
aromaticity; asymmetric catalysis; cascade reactions; heterocycles; magnesium
资金
- National Natural Science Foundation of China [21290182, 21321061, 21222206, 21432006]
- National Basic Research Program of China (973 Program) [2011CB808600]
A highly efficient asymmetric dearomatization of indoles was realized through a cascade reaction between 2-isocyanoethylindole and alkylidene malonates catalyzed by a chiral N, N'-dioxide/Mg-II catalyst. Fused polycyclic indolines containing three stereocenters were afforded in good yields with excellent diastereo- and enantioselectivities through a Michael/Friedel-Crafts/Mannich cascade. When 2-substituted 2-isocyanoethylindoles were used, spiroindoline derivatives were obtained through a Michael/Friedel-Crafts reaction.
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