期刊
CLINICAL JOURNAL OF PAIN
卷 25, 期 3, 页码 177-184出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/AJP.0b013e31818a744d
关键词
spinal cord injury; neuropathic pain; pain; tramadol
资金
- Norrbacka-Eugenia Foundation
Objectives: To assess the efficacy and safety of tramadol for relieving neuropathic pain after spinal cord injury (SCI). Methods: Thirty-six patient,, with SCI and neuropathic pain were enrolled in a randomized, double-blind, placebo-controlled trial, and 35 patients were included in the intention-to-treat analysis based on all patients taking at least 1 dose of study medication. Of the intention-to-treat population, 23 were randomized to treatment with tramadol and 12 to placebo. Patients were given study medication for 4 weeks, starting with 3 times 50 mg tramadol daily or 3 times 1 tablet of placebo. Results: At evaluation, 4 weeks after the treatment initiation, ratings of pain intensity were lower in those randomized to tramadol compared with those oil placebo. Pain severity scores oil the Multidimensional Pain Inventory had also decreased in patients oil tramadol. No between-group differences in pain affect were observed. Adverse events were substantial and caused 43% of those on tramadol and 17% on placebo to withdraw from the study. Discussion: Tramadol might he tried for neuropathic pain after SCI after the use of gabapentin pregabalin, and tricyclic antidepressants have been Found to be insufficient. Titration should be slow and individual, to minimize the risk of adverse events.
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