期刊
CLINICAL JOURNAL OF PAIN
卷 25, 期 5, 页码 401-406出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/AJP.0b013e31819655b3
关键词
migraine; nerve mechanical sensitivity; central sensitization; neurogenic inflammation
Objective: No Study has' previously analyzed pressure pain sensitivity of nerve trunks in migraine. This study aimed to examine the differences in mechanical pain sensitivity over specific nerves between patients With unilateral migraine and healthy controls. Methods: Blinded investigators assessed pressure pain thresholds (PPT) over the supra-orbital nerves (VI) and peripheral nerve trunks of both upper extremities (median, radial, and ulnar nerves) in 20 patients with strictly unilateral migraine and 20 healthy matched controls. Pain intensity after palpation over both supra-orbital nerves was also assessed. A pressure algometer was used to quantity PPT, whereas a 10-point numerical pain rate scale was used to evaluate pain to palpation over the supra-orbital nerve. Results: The analysis of covariance revealed that pain to palpation over the supra-orbital nerve was significantly higher (P < 0.001) on the symptomatic side (mean: 3.4, SD: 1.5) Lis compared with the nonsymptomatic side (mean: 0.5, SD: 1.2) in patients with migraine and both the dominant (mean: 0.2, SD: 0.4) and nondominant (mean: 0.3, SD: 0.5) sides in healthy controls. PPT assessed over the supra-orbital nerve on the symptomatic side (mean: 1.05, SD: 0.2 kg/cm(2)) was significantly lower (P < 0.05) than PPT measurements oil the nonsymptomatic side (mean: 1.35, SD: 0.3 kg/cm(2)) and either the dominant (mean: 1.9 SD: 0.2 kg/cm(2)) or nondominant (mean: 1.9, SD: 0.3 kg/cm(2)) sides in controls (P < 0.001). Finally PPT assessed over the median, ulnar, and radial nerves were significantly lower in patients with migraine as compared with controls (P < 0.001), Without side-to-side differences (P > 0.6). Conclusions: In patients with unilateral migraine, we found increased mechano-sensitivity of the supra-orbital nerve oil the symptomatic side of the)lead. Outside the head the same patients showed increased mechano-sensitivity of the main peripheral nerves of both upper limbs, without asymmetries. Such diffuse hypersensitivity of the peripheral nerves lends further evidence to the presence of a state of hyperexcitability of the central nervous system in patients with unilateral migraine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据