期刊
CLINICAL INFECTIOUS DISEASES
卷 68, 期 8, 页码 1420-1426出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciy696
关键词
cytomegalovirus; resistance; refractory; definitions; clinical trials
资金
- NCI NIH HHS [P30 CA016672] Funding Source: Medline
Despite advances in preventive strategies, cytomegalovirus (CMV) infection remains a major complication in solid organ and hematopoietic cell transplant recipients. CMV infection may fail to respond to commercially available antiviral therapies, with or without demonstrating genotypic mutation(s) known to be associated with resistance to these therapies. This lack of response has been termed resistant/refractory CMV and is a key focus of clinical trials of some investigational antiviral agents. To provide consistent criteria for future clinical trials and outcomes research, the CMV Resistance Working Group of the CMV Drug Development Forum (consisting of scientists, clinicians, regulatory officials, and industry representatives from the United States, Canada, and Europe) has undertaken establishing standardized consensus definitions of resistant and refractory CMV. These definitions have emerged from the Working Group's review of the available virologic and clinical literature and will be subject to reassessment and modification based on results of future studies.
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