期刊
CLINICAL INFECTIOUS DISEASES
卷 60, 期 4, 页码 627-638出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciu869
关键词
HIV infection; aging; myocardial infarction; end-stage renal disease; non-AIDS-defining cancers
资金
- National Institutes of Health: National Institute on Alcohol Abuse and Alcoholism [U24-AA020794, U01-AA020790, U01-AA020795, U01-AA020799, U24-AA022001, U24 AA022007, U10 AA013566-]
- National Heart, Lung, and Blood Institute [R01-HL095136, R01-HL090342]
- National Institute of Allergy and Infectious Diseases (NIAID) [U01-A1069918]
- National Institute of Mental Health [P30-MH062294]
- National Institute on Drug Abuse [R01DA035616]
- National Cancer Institute (NCI) [R01 CA173754]
- Agency for Healthcare Research and Quality [R01-HS018372]
- Veterans Health Administration Office of Research and Development [VA REA 08-266]
- Office of Academic Affiliations (Medical Informatics Fellowship)
- NIAID [K01-AI093197]
- NCI [F31-CA180775]
- National Institute of Diabetes and Digestive and Kidney Diseases [P01-DK056492]
- Department of Veterans Affairs, Veterans Health Administration [VA I01 RX000667]
- National Cancer Institute
Background. Although it has been shown that human immunodeficiency virus (HIV)-infected adults are at greater risk for aging-associated events, it remains unclear as to whether these events happen at similar, or younger ages, in HIV-infected compared with uninfected adults. The objective of this study was to compare the median age at, and risk of, incident diagnosis of 3 age-associated diseases in HIV-infected and demographically similar uninfected adults. Methods. The study was nested in the clinical prospective Veterans Aging Cohort Study of HIV-infected and demographically matched uninfected veterans, from 1 April 2003 to 31 December 2010. The outcomes were validated diagnoses of myocardial infarction (MI), end-stage renal disease (ESRD), and non-AIDS-defining cancer (NADC). Differences in mean age at, and risk of, diagnosis by HIV status were estimated using multivariate linear regression models and Cox proportional hazards models, respectively. Results. A total of 98 687 (31% HIV-infected and 69% uninfected) adults contributed >450 000 person-years and 689 MI, 1135 ESRD, and 4179 NADC incident diagnoses. Mean age at MI (adjusted mean difference, -0.11; 95% confidence interval [CI], -.59 to .37 years) and NADC (adjusted mean difference, -0.10 [95% CI, -.30 to .10] years) did not differ by HIV status. HIV-infected adults were diagnosed with ESRD at an average age of 5.5 months younger than uninfected adults (adjusted mean difference, -0.46 [95% CI, -.86 to -.07] years). HIV-infected adults had a greater risk of all 3 outcomes compared with uninfected adults after accounting for important confounders. Conclusions. HIV-infected adults had a higher risk of these age-associated events, but they occurred at similar ages than those without HIV.
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