期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 6, 页码 2122-2126出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201510597
关键词
antitumor agents; molybdenum oxide; nanosheets; photothermal therapy; rapid clearance
资金
- National Natural Science Foundation of China [51525203, 51302180, 51222203, 51472049]
- National 973 Program of China [2011CB911002, 2012CB932601]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Post-doctoral science foundation of China [2014M561706]
Molybdenum oxide (MoOx) nanosheets with high near-infrared (NIR) absorbance and pH-dependent oxidative degradation properties were synthesized, functionalized with polyethylene glycol (PEG), and then used as a degradable photothermal agent and drug carrier. The nanosheets, which are relatively stable under acidic pH, could be degraded at physiological pH. Therefore, MoOx-PEG distributed in organs upon intravenous injection would be rapidly degraded and excreted without apparent invivo toxicity. MoOx-PEG shows efficient accumulation in tumors, the acidic pH of which then leads to longer tumor retention of those nanosheets. Along with the capability of acting as a photothermal agent for effective tumor ablation, MoOx-PEG can load therapeutic molecules with high efficiencies. This concept of inorganic theranostic nanoagent should be relatively stable in tumors to allow imaging and treatment, while being readily degradable in normal organs to enable rapid excretion and avoid long-term retention/toxicity.
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