期刊
CLINICAL INFECTIOUS DISEASES
卷 54, 期 10, 页码 1495-1503出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/cis188
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资金
- French Agency for AIDS Research (ANRS)
- Institut National de la Sante et de la Recherche Medicale
- Lagadec family
Background. The stable immune control of human immunodeficiency virus (HIV) in long-term nonprogressors (LTNPs) with protective human leukocyte antigen (HLA) alleles raises the question of whether and how these alleles influence the immune distribution of the HIV reservoirs. Methods. Cell-associated HIV-DNA levels were quantified in blood sorted resting CD4 T-cell subsets from 8 LTNPs with and 10 without HLA-B(star)27 or HLA-B(star)57 alleles (HLA-B27/B57). Results. A remarkably lower infection level of central memory CD4 T cells (T-CM) was an exclusive feature that distinguished the HLA-B27/B57 HIV reservoirs from the other ones. In LTNPs, T-CM protection was correlated with preservation of T-CM counts, which correlated positively with the magnitude of HIV Gag-specific CD8 T cells. In HLA-B27/B57 LTNPs, a lower activation level of their memory CD4 T cells was associated with lower amounts of cell HIV-DNA in each resting memory CD4 subset and were also associated with higher ratios of HIV Gag-specific CD8 T cells per infected resting CD4 T cell (effector/target [E/T]). As a result, HLA-B27/B57 E/T ratios were negatively correlated with the contribution of memory CD4 T-cell subsets to the total HIV reservoirs. Conclusions. The potent antiviral immunity governed by the protective HLA-B27/B57 alleles, by limiting T-CM infection and pool exhaustion, are associated with a reduced T-CM contribution to the HIV reservoir.
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