期刊
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
卷 388, 期 -, 页码 116-122出版社
ELSEVIER
DOI: 10.1016/j.jmmm.2015.04.017
关键词
PEG/lactobionic acid-chitosan; Magnetism; Nanopartides; Liver targeting; Magnetic resonance imaging
资金
- National Natural Science Foundation of China [21201149, 51073133]
- Natural Science Foundation of Jiangsu Province [BK2012259]
- Testing Center of Yangzhou University
- Jiangsu Province Postdoctoral Science Foundation
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Biofunctionalized chitosan@Fe3O4 nanoparticles are synthesized by combining Fe3O4 and CS chemically modified with PEG and lactobionic acid in one step. The biofunctionalized nanoparticles are characterized by TEM, X-ray, DLS, zeta-potential and magnetic measurements. The in vitro and in vivo behaviors of the biofunctionalized nanoparticles, especially, the cytotoxicity, the protein resistance, metabolism and iron toxicity are assessed. The functional groups, PEG enable the nanoparticles more biocompatible and the lactobionic acid groups enable liver targeting. The potential applications of the nanoparticles in liver magnetic resonance imaging are confirmed. The results demonstrated that the nanoparticles are suspension stability, non-cytotoxicity, non-tissue toxicity and sensitive in liver magnetic resonance imaging, representing potential tools for applications in the biomedical field. (C) 2015 Elsevier B.V. All rights reserved,
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