期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 26, 页码 7492-7509出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201500088
关键词
disassembly; kinetics; self-immolation; self-immolative spacers
资金
- French ANR (Kituse, France BioImaging, Morphoscope2)
Self-immolative spacers are covalent assemblies tailored to correlate the cleavage of two chemical bonds after activation of a protective part in a precursor: Upon stimulation, the protective moiety is removed, which generates a cascade of disassembling reactions leading to the temporally sequential release of smaller molecules. Originally introduced to overcome limitations for drug delivery, self-immolative spacers have gained wide interest in medicinal chemistry, analytical chemistry, and material science. For most applications, the kinetics of the disassembly of the activated self-immolative spacer governs functional properties. This Review addresses kinetic aspects of self-immolation. It provides information for selecting a particular self-immolative motif for a specific demand. Moreover, it should help researchers design kinetic experiments and fully exploit the rich perspectives of self-immolative spacers.
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