Recurrent, Multifocal Mycobacterium avium-intercellulare Infection in a Patient with Interferon-gamma Autoantibody

We describe a patient who experienced severe osteomyelitis because of Mycobacterium avium-intercellulare infection and high-titered autoantibodies against interferon-gamma. In addition to antimycobacterial chemotherapy, we treated our patient with plasmapheresis and cyclophosphamide. The treatment induced a remission after 3 years of follow-up.