期刊
CLINICAL INFECTIOUS DISEASES
卷 49, 期 9, 页码 E96-E99出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/644501
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资金
- NCRR NIH HHS [UL1 RR024150, 1 UL1 RR024150, UL1 RR024150-01] Funding Source: Medline
Toll-like receptor 2 (TLR2) serves as a pattern recognition receptor that signals the presence of cytomegalovirus. Herein, we report that R753Q polymorphism paralyzes TLR2-mediated immune signaling in cells exposed to cytomegalovirus glycoprotein B. This immunologic impairment could serve as a biologic mechanism underlying the association between the TLR2 R753Q polymorphism and cytomegalovirus disease in humans.
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