期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 45, 页码 13170-13184出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201502493
关键词
alkylation; asymmetric catalysis; carbanions; nitriles; synthetic methods
资金
- University of the Basque Country UPV/EHU [UFI 11/22]
- Basque Government [IT-628-13]
- Ministerio de Economia y Competitividad [CTQ2013-47925-C2]
Alkylnitriles are one of the most ubiquitous nitrogen-containing chemicals and are widely employed in reactions which result in nitrile-group conversion into other functionalities. Nevertheless, their use as carbon pronucleophiles in carbon-carbon bond-forming reactions has been hampered by difficulties associated mainly with the catalytic generation of active species, that is, -cyano carbanions or metalated nitriles. Recent investigations have addressed this challenge and have resulted in different modes of alkylnitrile activation. This review illustrates these findings, which have set the foundation for the development of practical and conceptually new catalytic, direct cyanoalkylation methodologies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据